NMS-P715 analog

"目录号: HY-14712

Cell Cycle/DNA DamageCytoskeleton-

NMS-P715 analog是NMS-P715的类似物，NMS-P715是首个高效、ATP竞争性Mps1抑制剂（IC50值为8nM）。

Mps1

相关产品

Mps1-IN-1-AZ3146-CFI-402257-BAY 1161909-BAY1217389-MPI-0479605-NMS-P715-Mps1-IN-2-Mps1-IN-3-

生物活性

Description

NMS-P715 analog is the analog of NMS-P715, which is the first selective, ATP-competitive and orally bioavailable MPS1 small-molecule inhibitor(IC50=8 nM); selectively reduces cancer cell proliferation, leaving normal cells almost unaffected.

References

[1].Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64.